br Although their influence is not
Although their influence is not strong, some bacteria related to dental caries and periodontal disease also suggest that the cancer risk can be reduced by maintaining good oral hygiene.
Despite the microbiota distribution evaluation at this time, it has been reported that the ratio as well as the number of bacteria influence disease onset . There is a possibility of identifying new causative bacteria for the onset by comparing the number of bacteria.
In addition, bacteria as well as fungi are involved in the for-mation of oral microbiota. It is known that Candida and other fungi are detected at high proportions in the oral cavity if the immune status is reduced as in the elderly and HIV patients [43,44]. It is suggested that these fungal species are also associated with oral cancer and other cancers, but the specifics of how they are involved are not clear . In recent years, analysis of microbiota using NGS has been carried out widely, but research on the characteristics of the fungal flora and their relation to the microbiota in OSCC pa-tients will be necessary in the future.
In this study, we compared the oral microbiota of 60 Japanese oral cancer patients with 80 non-cancer individuals and found high bacterial RGX-104 and a change in the ratio of some bacterial species.
Conflict of interest
The authors have no conflict of interest.
CRediT authorship contribution statement
Yasuharu Takahashi: Data curation, Writing - original draft.
Jonguk Park: Formal analysis, Writing - original draft. Koji
Hosomi: Formal analysis. Tomonori Yamada: Data curation. Ayaka
Kobayashi: Data curation. Yuji Yamaguchi: Data curation. Susumu
Iketani: Data curation. Jun Kunisawa: Formal analysis. Kenji
Mizuguchi: Formal analysis. Nobuko Maeda: Writing - original
draft. Tomoko Ohshima: Writing - original draft.
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